HIGHER EFFICACY
SODIUM SUCCINATE
Affects the main factors of OA progression:
Hypoxia
Energy Deficiency
Acidosis
Free-radical Lipid Peroxidation
Structural & Functional Impairments Of The Cartilage Matrix
KREBS CYCLE / CITRIC ACID CYCLE (PART)
SUCCINATE is an intermediate in the Krebs Cycle, and energy-yielding process
CARTILAGE MODIFYING EFFECTS OF DIART
45 days (Pre-Clinial Study)
"With DIART, complete filling of the bony-cartilaginous defect by the regenerate in 80% cases"
Monopreparation of HA
DIART Preparation
90 days post-injury
Monopreparation of HA
Partial filling of the bony-cartilaginous defect by the regenerate in administration of mono-preparation of hyaluronic acid. Loss of luster and appearance of roughness of the articular cartilage
DIART Preparation
Complete filling of the bony-cartilaginous defect by the regenerate in intra-articular administration of hyaluronic acid with sodium succinate. (DIART preparation)
Pain Relief & Activity Score
DEVELOPMENT OF DEGENERATIVE CHANGES
(KL OA GRADE 0 -III; 0 = Normal, III = Severe OA )
IN TRAUMATIC INJURIES
3 - 12 Months
Results were maintained at 12 months without any Grade III
DIART Group n=44
(DIART weekly injections after absence of
all inflammation symptoms and exudate
(average 5-6 weeks)
6 Months
12 Months
Significant progression of OA in Comparison group
Comparison Group n=42
DIART Group n=44
(DIART weekly injections after absence of all inflammation symptoms and exudate
(average 5-6 weeks)
Comparison Group n=42
HOW DIART HELPS
DIART insertion directly to the seat of the pathological process helps to normalize key pathological factors* in traumatic knee injuries and also slows down the progression of OA while restoring the antioxidant defense in the affected joint.
Proven to slow down OA progression
Viscoinduction (stabilised)
